top of page
Search

Rosai-Dorfman Disease

  • Painless B/L Lymphadenopathy, fever, leukocytosis

  • H&E: Marked sinus expansion by histiocytes, emperipolesis (lymphocytes, neutrophils, plasma cells in cytoplasmic vacuoles)

  • IHC: S100+, CD68+, CD163+, CD1a-, Langerin -

  • Non clonal. BRAF V600 E mutation in rare cases have been reported

  • Good prognosis, spontaneous regression







 
 
 

Comments

bottom of page