SEROUS CYSTADENOMA
MORPHOLOGY
· Gross: Multilocular, sponge-like, or honeycomb appearance with a central stellate fibrous scar
· Microscopy: Cysts lined by a single layer of cells with defined cell borders
· Composed of bland, uniform, cuboidal cells with clear, glycogen-rich cytoplasm and small round nuclei
· Glycogen→ stains with PAS (and digested by diastase)
· IHC: Positive for inhibin, cytokeratin, GLUT-1, and MUC6
OTHER HIGH YIELD POINTS
· F: M ratio 3:1, usually seen in older women (>60 years of age)
· Associated with von Hippel Lindau Syndrome (VHL)
· Most are benign with excellent prognosis and low incidence of metastasis→ Serous cystadenocarcinoma
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